Main menu
 

 

 

nanoXIM HAp pastes are nano-hydroxyapatite water based pastes specially recommended to manufacture bone graft substitutes such as injectables for bone regeneration and implants for hard tissues.

The hydroxyapatite nanoparticles comprised in these products form a perfectly aligned structure of nanocrystals.

Due to the similarity between nano-hydroxyapatite and mineralized bone, nanoXIM HAp pastes have a high affinity to hard tissues, establishing chemical bonds with the host tissue.

 

 

   Benefits

 

Promotes fast bone regeneration and an early vascularization due to their osteoconductive and osteostimulative properties
Encourages protein adsorption and osteoblast adhesion
Enhances osteoblast functions
Biocompatible material
Resorbable material replaced by new bone during the healing process
Optimal defect filling capacity due to pasty consistency

 

   Features

 

Hydroxyapatite phase purity (100%)
Hydroxyapatite nanoparticles (< 50 nm)
High surface area (≥ 80 m2/g)
Synthetic material

 

 

 

 

   Technical Data Sheet

 

nanoXIM•HAp100 is a series of synthetic nano-hydroxyapatite aqueous pastes, manufactured and supplied in two different concentrations, 15 and 30 wt%.

These products comprise nano-hydroxyapatite particles with typical particle size below 50 nm in a rod-like shape (typically 30-40 nm length and 5-10 nm width) suspended in pure water.

 

Reference  Hydroxyapatite (wt%) Specific surface area,
BET (m2/g)
Heavy metals,
as Pb (ppm)
nanoXIM•HAp102 15±1.0 ≥ 80 ≤ 20
nanoXIM•HAp103 30±3.0 ≥ 80 ≤ 20
Disclaimer: nanoXIM products are supplied in bulk and in non-sterile form.
turn-your-device

 

nanoXIM.HAp Paste

High Resolution TEM of
nanoXIM.HAp Paste

Electron crystallography image
of nanoXIM.HAp Paste

 

   Information Request


 

 

 

 

Stem Cells Applications of nano-HAp

 

During bone regeneration, Human Mesenchymal Stem Cells (HMSCs) play an important role as they are recruited to the injured place and differentiate into bone cells, enabling the regeneration process.

Considering the importance of these cells, it was evaluated the biological performance of nanoXIMHAp102 in the proliferation and osteoblastic differentiation of HMSCs.

 

Download Whitepaper

Human Mesenchymal Stem Cells (HMSCs) cultured in the
presence of nanoXIM HAp Paste present typical cytoskeleton
organization.

 

Supercritical CO2 assisted process for the production of high-purity and sterile nano-hydroxyapatite/chitosan hybrid scaffolds

G. Ruphuy, M. Souto-Lopes, D. Paiva, P. Costa, A.E. Rodrigues, F.J. Monteiro, C.L. Salgado, M.H. Fernandes, J.C. Lopes, M.M. Dias, M.F. Barreiro, “Supercritical CO2 assisted process for the production of high-purity and sterile nano-hydroxyapatite/chitosan hybrid scaffolds”, J Biomed Mater Res Part B, DOI: 10.1002/jbm.b.33903 (2017).

learn more

The relationship between particle morphology and rheological properties in injectable nano-hydroxyapatite bone graft substitutes

Y. Ryabenkova, A. Pinnock, P.A. Quadros, R.L. Goodchild, G. Möbus, A. Crawford, P.V. Hatton, C.A. Miller, “The relationship between particle morphology and rheological properties in injectable nano-hydroxyapatite bone graft substitutes”, Materials Science and Engineering: C, 75, p. 1083, (2017).

learn more

Comparison of nanoparticular hydroxyapatite pastes of different particle content and size in a novel scapula defect model

V. Hruschka, S. Tangl, Y. Ryabenkova, P. Heimel, D. Barnewitz, G. Möbus, C. Keibl, J. Ferguson, P. Quadros, C. Miller, R. Goodchild, W. Austin, H. Redl, T. Nau, “Comparison of nanoparticular hydroxyapatite pastes of different particle content and size in a novel scapula defect model”, Nature Scientific Reports 7, Article number: 43425; doi: 10.1038/srep43425 (2017).

learn more

Antibacterial activity and biofilm inhibition by surface modified titanium alloy medical implants following application of silver, titanium dioxide and hydroxyapatite nanocoatings

A. Besinis, S. D. Hadi, H. R. Le, C. Tredwin, R. D. Handy, “Antibacterial activity and biofilm inhibition by surface modified titanium alloy medical implants following application of silver, titanium dioxide and hydroxyapatite nanocoatings”, Nanotoxicology, DOI: 10.1080/17435390.2017.1299890 (2017).

learn more

Characteristics and in vitro response of thin hydroxyapatite–titania films produced by plasma electrolytic oxidation of Ti alloys in electrolytes with particle additions

W. K. Yeung, I. V. Sukhorukova, D. V. Shtansky, E. A. Levashov, I. Y. Zhitnyak, N. A. Gloushankova, P. V. Kiryukhantsev-Korneev, M. I. Petrzhik, A. Matthews, A. Yerokhin, “Characteristics and in vitro response of thin hydroxyapatite–titania films produced by plasma electrolytic oxidation of Ti alloys in electrolytes with particle additions”, The Royal Society of Chemistry Advances, 6, p. 12688 (2016).

learn more

Mesh composition for repairing or the regeneration of tissues and methods thereof

F.J. Monteiro, N. Ribeiro, S.R. Sousa, L. Moroni, “Mesh composition for repairing or the regeneration of tissues and methods thereof”, WO/2015/162559A1.

learn more

Characterization and corrosion evaluation of TiO2:n-HA coatings on titanium alloy formed by plasma electrolytic oxidation

D. Dzhurinskiy, Y.Gao, W.-K. Yeung, E. Strumban, V. Leshchinsky, P.-J.Chu, A. Matthews, A. Yerokhin, R.Gr. Maev, “Characterization and corrosion evaluation of TiO2:n-HA coatings on titanium alloy formed by plasma electrolytic oxidation”, Surface & Coatings Technology, 269, p.258 (2015).

learn more

A biocomposite of collagen nanofibers and nanohydroxyapatite for bone regeneration

N. Ribeiro, S.R. Sousa, C.A. van Blitterswijk, L. Moroni, F.J. Monteiro, “A biocomposite of collagen nanofibers and nanohydroxyapatite for bone regeneration, Biofabrication, 6(3), p. XXX (2014). 

learn more

Biofunctional composite coating architectures based on polycaprolactone and nanohydroxyapatite for controlled corrosion activity and enhanced biocompatibility of magnesium AZ31 alloy

A. Zomorodian, M.P. Garcia, T. Moura e Silva, J.C.S. Fernandes, M.H. Fernandes, M.F. Montemor, “Biofunctional composite coating architectures based on polycaprolactone and nanohydroxyapatite for controlled corrosion activity and enhanced biocompatibility of magnesium AZ31 alloy”, Materials Science and Engineering C, 48, p. 434 (2014).

learn more

Preparation of hydroxyapatite nanodispersions in the presence of chitosan by ultrasonication

G. Ruphuy, J.C. Lopes, M. Dias, M.F. Barreiro, “Preparation of hydroxyapatite nanodispersions in the presence of chitosan by ultrasonication”, Conference Paper for International Conference on Biobased Materials and Composites (ICBMC), 13-16 May, Montreal, Canada (2014).

learn more

An experimental procedure for Reaction Injection Moulding – RIM – materials formulation design

M. V. Torres, “An experimental procedure for Reaction Injection Moulding – RIM – materials formulation design”, PhD Thesis in Chemical and Biological Engineering, Department of Chemical Engineering, University of Porto (2014).

learn more

Resposta biológica à implantação subcutânea de nanopartículas de hidroxiapatite em ratos diabéticos

V. Reis, “Resposta biológica à implantação subcutânea de nanopartículas de hidroxiapatite em ratos diabéticos”, MSc Thesis Biologia Clínica Laboratorial, Universidade de Trás-os-Montes e Alto Douro (2013).

learn more

Insertion torques influenced by bone density and surface roughness of HA–TiO2 coatings

T. Cheng, Y. Chen, X. Nie, “Insertion torques influenced by bone density and surface roughness of HA–TiO2 coatings”, Thin Solid Films 549, p. 123 (2013).

learn more

Effect of the nanohydroxyapatite Formulation NanoXIM.HAp102 on the Proliferation and Osteogenic Differentiation of Human Bone Mesenchymal Stem Cells

E. Pires, "Effect of the nanohydroxyapatite Formulation NanoXIM.HAp102 on the Proliferation and Osteogenic Differentiation of Human Bone Mesenchymal Stem Cells", Integrated MSc Thesis in Bioengineering, Faculty of Engineering, University of Porto (2013).

Citocompatibilidade de matrizes de quitosano/fosfato de cálcio

F. Pinto, “Citocompatibilidade de matrizes de quitosano/fosfato de cálcio (Cytocompatility of chitosan/calcium phosphate scaffolds)” MSc Thesis, Aveiro University (2013). 

learn more

Graphene oxide and hydroxyapatite as fillers of polylactic acid nanocomposites: preparation and characterization.

P.A.A.P. Marques, G. Gonçalves, M.K. Singh, J. Grácio, “Graphene oxide and hydroxyapatite as fillers of polylactic acid nanocomposites: preparation and characterization.”, Journal of Nanoscience and Nanotechnology, 12, p. 6686 (2012).

learn more

Chitosan based scaffolds for bone regeneration

L. Marbelia, “Chitosan based scaffolds for bone regeneration” MSc Thesis, University of Aveiro (2011).

learn more

Matrizes de quitosano/grânulos bifásicos para libertação de fármacos

Mesquita, “Matrizes de quitosano/grânulos bifásicos para libertação de fármacos (Chitosan/biphasic granules scaffolds for drug delivery)” MSc Thesis, Aveiro University (2012).

learn more