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nanoXIM•CarePaste is a synthetic nano-hydroxyapatite water based suspension ingredient specially designed to be easily incorporated in oral care products such as toothpastes, mouthwashes, gels and other professional dental products.

The hydroxyapatite nanoparticles comprised in nanoXIM•CarePaste form a perfectly aligned structure of nanocrystals identical to enamel hydroxyapatite which enables enamel remineralization.

Due to the nanometric size of hydroxyapatite particles, nanoXIM•CarePaste is able to seal the dentin tubules and prevent nerve exposure to external stimuli, resulting in reduced dental hypersensitivity.

 

 

   Benefits

 

Reduction of dental hypersensitivity by effective occlusion of dentin tubules

Promotion of enamel remineralization due to high affinity for binding with teeth surface

Smoothes and protects teeth surface from the damage caused by acids in food and drink

 

   Features

 

Hydroxyapatite nanoparticles (< 50 nm)

High surface area (≥ 80 m2/g)

Low Relative Dentin Abrasivity (RDA < 10)

Synthetic material

Self-preserved product (Parabens Free)

Shelf life 2 years

 

 

 

   Technical Data Sheet

 

nanoXIM•CarePaste comprises nano-hydroxyapatite particles with typical particle size below 50 nm in a rod-like shape (typically 30-40 nm length and 5-10 nm width) suspended in pure water with hydroxyapatite concentration of 15.5 wt%.

 

Reference  Hydroxyapatite
(wt%)
Potassium
Chloride (wt%)
Microbial
content1 (cfu/g)
Heavy metals,
as Pb (ppm)
Shelf life (years)
nanoXIM•CarePaste 15.5±0.5 4.5±0.5 ≤ 100 ≤ 20 2
(1) Total Aerobic Mesophilic Microorganisms (Bacteria, Yeasts and mold)
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nanoXIM•CarePaste

High Resolution TEM of
nanoXIM•CarePaste

Electron crystallography image
of nanoXIM•CarePaste

 

   Information Request

 

 

 

 

 

Effectiveness of nanoXIM•CarePaste on dentin tubule occlusion and enamel remineralization

 

Dental hypersensitivity is a common and relevant clinical problem.

This condition arises as a result of continuous teeth erosion and it is characterized by a short and sharp pain, being a significant concern for patients. Dental hypersensitivity is usually treated by incorporating desensitizing agents in toothpastes.

nanoXIM•CarePaste when used in toothpaste formulations effectively occludes the dentinal tubules and consequently reduces dental hypersensitivity. It is also demonstrated that toothpastes containing nanoXIM•CarePaste are able to reduce early carious lesions by remineralizing the enamel surface.

 

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Clinical efficacy of a dentifrice containing nanoXIM•CarePaste

 

This clinical trial compared the effectiveness of a toothpaste containing nanoXIM•CarePaste in reducing dental hypersensitivity, in comparison with two other dentifrices without nanoXIM•CarePaste.

The toothpaste with nanoXIM•CarePaste performed better than dentifrice 1 and dentifrice 2 in 75 % and 100 % of the cases, respectively.

Therefore, nanoXIM•CarePaste was the most effective in the treatment of dental hypersensitivity allowing a superior pain reduction after 3 months. In addition, nanoXIM•CarePaste provided a faster pain relief immediately after 2 weeks of treatment for all the tests performed.

 

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After 2 weeks of treatment, the nanoXIM•CarePaste toothpaste provided a superior pain relief when compared with Dentifrice 1 and Dentifrice 2

 

 

Nano-hydroxyapatite toothpaste vs Fluoride toothpaste in reducing dental hypersensitivity

 

In the present clinical trial, it was evaluated the efficacy of a toothpaste containing nanoXIM•CarePaste in reducing dental hypersensitivity, in comparison with a toothpaste containing fluoride. Hypersensitivity was assessed using tactile and air blast stimuli.

This study revealed that the toothpaste containing nanoXIM•CarePaste was able to significantly reduce dental hypersensitivity, for both tactile and air blast stimuli, which was not achieved with the placebo and fluoride toothpaste.

 

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nanoXIM•CarePaste reduced dental hypersensitivity immediately after 2 weeks, providing a fast and effective pain relief.

 

 

 

 

 

 

Comparing the effectiveness of four desensitizing toothpastes on dentinal tubule occlusion: A scanning electron microscope analysis
 

A. Jena, S. Kala, G. Shashirekha, “Comparing the effectiveness of four desensitizing toothpastes on dentinal tubule occlusion: A scanning electron microscope analysis”, Journal of Conservative Dentistry, 20(4), p. 269 (2017).

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Poly(Nisopropylacrylamide)-hydroxyapatite nanocomposites as thermoresponsive filling materials on dentinal surface and tubules

P. Tempesti, G.S. Nicotera, M. Bonini, E. Fratini, P. Baglioni, “Poly(Nisopropylacrylamide)-hydroxyapatite nanocomposites as thermoresponsive filling materials on dentinal surface and tubules”, Journal of Colloid and Interface Science doi: http://dx.doi.org/10.1016/j.jcis.2017.09.001 (2017).

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Evaluation of efficiency of two nanohydroxyapatite remineralizing agents with a hydroxyapatite and a conventional dentifrice: A comparative In vitro study

A. Singh, B. Shetty, C.M. Mahesh, V.P. Reddy, B.S. Chandrashekar, S. Mahendra, “Evaluation of efficiency of two nanohydroxyapatite remineralizing agents with a hydroxyapatite and a conventional dentifrice: A comparative In vitro study”, The Journal of Indian Orthodontic Society, 51(2), p. 92 (2017).

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Reducing dentine hypersensitivity with nano-hydroxyapatite toothpaste: a double-blind randomized controlled trial

M. Vano, G. Derchi, A. Barone, R. Pinna, P. Usai, U. Covani, “Reducing dentine hypersensitivity with nano-hydroxyapatite toothpaste: a double-blind randomized controlled trial”, Clinical Oral Investigations, p. 1 doi:10.1007/s00784-017-2113-3 (2017).

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Effect of nano-hydroxyapatite toothpaste on microhardness of artificial carious lesions created on extracted teeth
 

A. Ebadifar, M. Nomani, S.A. Fatemi, “Effect of nano-hydroxyapatite toothpaste on microhardness of artificial carious lesions created on extracted teeth”, Journal of Dental Research, Dental Clinics, Dental Prospects, 11(1), p. 14. (2017).

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An In-vitro Comparison of Nano Hydroxyapatite, Novamin and Proargin Desensitizing Toothpastes - A SEM Study

R. Kulal, I. Jayanti, S. Sambashivaiah, S. Bilchodmath, “An In-vitro Comparison of Nano Hydroxyapatite, Novamin and Proargin Desensitizing Toothpastes - A SEM Study”, Journal of Clinical and Diagnostic Research 10(10), p. 51 (2016).

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Reduction in Dental Hypersensitivity with Nano-Hydroxyapatite, Potassium Nitrate, Sodium Monoflurophosphate and Antioxidants

S. B. Low, E. P. Allen, E. D. Kontogiorgos, “Reduction in Dental Hypersensitivity with Nano-Hydroxyapatite, Potassium Nitrate, Sodium Monoflurophosphate and Antioxidants”, The Open Dentistry Journal, 9, p. 92 (2015).

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Estudio comparativo in vitro del grado de remineralización del esmalte dental con el uso de nanopartículas de hidroxiapatita en dientes extraídos con y sin brackets cementados en ellos

M. Jiménez Ochoa, “Estudio comparativo in vitro del grado de remineralización del esmalte dental con el uso de nanopartículas de hidroxiapatita en dientes extraídos con y sin brackets cementados en ellos”, MSc Thesis Ortodoncia, Universidad San Francisco de Quito, Ecuador (2015).

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Tooth bleaching with hydrogen peroxide and nano-hydroxyapatite: A 9-month follow-up randomized clinical trial.

M. Vano, G. Derchi, A. Barone, A. Genovesi, U. Covani, “Tooth bleaching with hydrogen peroxide and nano-hydroxyapatite: A 9-month follow-up randomized clinical trial.”, International Journal of Dental Hygiene, 13(4), p. 301 (2015).

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Comparison of efficacy of three different desensitizing agents for in-office relief of dentin hypersensitivity: A 4 weeks clinical study

A. Jena, G. Shashirekha, “Comparison of efficacy of three different desensitizing agents for in-office relief of dentin hypersensitivity: A 4 weeks clinical study”, Journal of Conservative Dentistry, 18(5), p. 389 (2015).

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Evaluation of the Efficacy of Commercially Available Nano-Hydroxyapatite Paste as a Desensitizing Agent

M. Amin, R. Mehta, S. Duseja, K. Desai, “Evaluation of the Efficacy of Commercially Available Nano-Hydroxyapatite Paste as a Desensitizing Agent”, Advances in Human Biology 5(1), p. 34 (2015).

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Evaluation of Dentifrice Containing Nano-hydroxyapatite for Dentinal Hypersensitivity: A Randomized Controlled Trial

N. M. Gopinath, J. John, N. Nagappan, S. Prabhu, E. S. Kumar, “Evaluation of Dentifrice Containing Nano-hydroxyapatite for Dentinal Hypersensitivity: A Randomized Controlled Trial”, Journal of International Oral Health, 7(8), p. 118 (2015).

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Effectiveness of nano-hydroxyapatite toothpaste in reducing dentin hypersensitivity: A double-blind randomized controlled trial

M. Vano, G. Derchi, A. Barone, U. Covani, “Effectiveness of nano-hydroxyapatite toothpaste in reducing dentin hypersensitivity: A double-blind randomized controlled trial”, Quintessence International, 45(8), p. 703 (2014). 

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An In-Vivo Comparative Study of the Efficacy of Propolis, Nano-Hydroxyapatite and Potassium Nitrate Containing Desensitizing Agents

N. VJ, S. Thakur, “An In-Vivo Comparative Study of the Efficacy of Propolis, Nano-Hydroxyapatite and Potassium Nitrate Containing Desensitizing Agents”, Research and Reviews: Journal of Dental Sciences, 2(2), p. 113 (2014). 

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A Comparison of Clinical Efficacy of Dentifrices Containing Calcium Sodium Phosphosilicate, Nanoparticle Hydroxyapatite and a Dentifrice Containing Casein Phosphopeptide Amorphous Calcium Phosphate on Dentinal Hypersensitivity

Pinojj, A. Shetty, D. Shetty, S. Shetty, “A Comparison of Clinical Efficacy of Dentifrices Containing Calcium Sodium Phosphosilicate, Nanoparticle Hydroxyapatite and a Dentifrice Containing Casein Phosphopeptide Amorphous Calcium Phosphate on Dentinal Hypersensitivity - A Comparative Triple Blind Randomized Study”, Advances in Human Biology, 4(2) p. 57 (2014).

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Evaluation of the Clinical Efficacy of a new Desensitizing Tooth Paste Containing Nano-crystalline Hydroxyapatite in Dentine Hypersensitivity Patients : A Double Blind Randomized Controlled Clinical Trial

P. Verma, U. Gupta, V. Dodwad, B. Kukreja, K. Arora, “Evaluation of the Clinical Efficacy of a new Desensitizing Tooth Paste Containing Nano-crystalline Hydroxyapatite in Dentine Hypersensitivity Patients : A Double Blind Randomized Controlled Clinical Trial”, Journal of Dental Specialities, 1(2), p. 47 (2013).

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