nanoXIM HAp powders are micrometric aggregates of hydroxyapatite nanoparticles.
These products are used in the manufacturing of biocompatible bone graft substitutes (e.g. porous granules and scaffolds for bone regeneration) and 3D printed implants.
Due to the similarity between nano-hydroxyapatite and mineralized bone, nanoXIM HAp powders have a high affinity to hard tissues as they form chemical bonds with the host tissue resulting in an improved biological performance.
Benefits
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Promotes bone regeneration and vascularization |
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Osteoconductive and osteostimulative |
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Enhances osteoblast functions |
|
Biocompatible material |
Features
|
Pure hydroxyapatite |
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Micron-sized powders |
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Narrow particle size distribution |
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Synthetic material |
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Complies with heavy metals and Ca/P ratio according to ISO 13779 |
Technical Data Sheet
nanoXIM•HAp200
nanoXIM•HAp200 is a series of nanostructured synthetic hydroxyapatite powders, manufactured and supplied in two different particle sizes, 5 and 10 μm.
This feature is achieved in the drying process by spray dryer technique where the nanoparticles in liquid phase are dried as spherical aggregates with a high surface area.
| Reference | Particle size, d50 (μm) |  |
| nanoXIM•HAp202 | 5.0±1.0 | ADD |
| nanoXIM•HAp203 | 10.0±2.0 | ADD |
Physical appearance |
SEM of nanoXIM.HAp200 |
Electron crystallography |
nanoXIM•HAp600
nanoXIM•HAp600 is a series of synthetic calcined hydroxyapatite powders composed by micron-sized particles.
These powders are heat-treated to obtain products with a low surface area and high crystallinity.
| Reference | Particle size, (μm) |
|
| nanoXIM•HAp602 |
d10 : ≤ 5 d50 : ≤ 15 d90 : ≤ 25 |
Physical appearance |
SEM of nanoXIM.HAp602 |
SEM of nanoXIM.HAp602 |
Information Request
The formation of a stable microvasculature is an essential process to ensure a successful regeneration of bone tissue.
Download Whitepaper
The viability and proliferation of bone cells are essential during bone regeneration. In this study, it was evaluated the viability and proliferation of MG63 cells (osteoblast-like cells) cultured on substrates produced with nanoXIM•HAp202, in comparison with the ones produced with micro HAp.
Download Whitepaper
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Z. Doni, A.C. Alves, F. Toptan, L.A. Rocha, M. Buciumeanu, L. Palaghian, F.S. Silva, “Tribocorrosion behaviour of hot pressed CoCrMo-HAP biocomposites” Tribology International, 91, p. 221 (2015).
M. Morra, G. Giavaresi, M. Sartori. A. Ferrari, A. Parrilli, D. Bollati, R.R. Baena, C. Cassinelli, M. Fini, , “Surface chemistry and effects on bone regeneration of a novel biomimetic synthetic bone filler” J Mater Sci: Mater Med 26(4), p. 159 (2015).
F. Munarin, P. Petrini, R. Gentilini, R.S. Pillai, S. Dirè, M.C. Tanzi, V.M. Sglavo,“Micro- and nano-hydroxyapatite as active reinforcement for soft biocomposites”, International Journal of Biological Macromolecules, 72, p. 199 (2015).
L. Grenho, J. Barros, C. Ferreira, V.R. Santos, F.J. Monteiro, M.P. Ferraz, M.E. Cortes, “In vitro antimicrobial activity and biocompatibility of propolis containing nanohydroxyapatite”, Biomedical Materials, 10, p. XXX (2015).
L.R. Rodrigues, M.S. Laranjeira, M.H. Fernandes, F.J. Monteiro, C.A.C. Zavaglia, “HA/TCP scaffolds obtained by sucrose crystal leaching method: Preliminary in vitro Evaluation”, Materials Research, 17(4), p. 811 (2014).
K. Naik, "Sintering of Ceramic Materials Under Electric Field", PhD Thesis in Materials Science Engineering, Department of Industrial Engineering, University of Trento (2014).
M.R. Davarpanah, H.A. Khoshhosn, M. Harati, S.A. Nosrati, M. Zoghi, M. Mazidi, M.G. Maragheh, “Optimization of fundamental parameters in routine production of 90Y-hydroxyapatite for radiosynovectomy”, Journal of Radioanalytical and Nuclear Chemistry, 302(1), p. 69 (2014).
J. Barros, L. Grenho, C.M. Manuel, C. Ferreira, L. F. Melo, O.C. Nunes, F.J. Monteiro, M.P. Ferraz, “Influence of nanohydroxyapatite surface properties on Staphylococcus epidermidis biofilm formation”, Journal of Biomaterials Applications, 28(9), p. 1325 (2014).
O.Y. Alothman, H. Fouad, S. M. Al-Zahrani, A. Eshra, M. F. A. Rez, S. G. Ansari, “Thermal, creep-recovery and viscoelastic behavior of high density polyethylene/hydroxyapatite nano particles for bone substitutes: effects of gamma radiation”, BioMedical Engineering OnLine, 13(1) p. 125 (2014).
L. Grenho, F.J. Monteiro, M.P. Ferraz, “In vitro analysis of the antibacterial effect of nanohydroxyapatite–ZnO composites”, Journal of Biomedical Materials Research Part A, 102(10), p. 3726 (2014).
K. Piedade, “Influence of vancomycin controlled release from heparinized collagen/nanophased hydroxyapatite granules on osteoblast and osteoclast cells”, Master Thesis in Pharmaceutical Biotechnology, Faculty of Pharmacy of Coimbra University, Portugal (2014).
M. V. Torres, “An experimental procedure for Reaction Injection Moulding – RIM – materials formulation design”, PhD Thesis in Chemical and Biological Engineering, Department of Chemical Engineering, University of Porto (2014).
S.D. Hadi, “The Antibacterial Properties and Biocompatibility of Silver and Hydroxyapatite Nanoparticles Coating on Dental Implants”, MSc Thesis, School of Biological Sciences, Faculty of Science and Environment, University of Plymouth, UK (2014).
M.S. Laranjeira, M.H. Fernandes, F.J. Monteiro, “Response of Monocultured and Co-Cultured Human Microvascular Endothelial Cells and Mesenchymal Stem Cells to Macroporous Granules of Nanostructured-Hydroxyapatite Agglomerates”, Journal of Biomedical Nanotechnology, 9(9), p. 1594 (2013).
J. Barros, L. Grenho, C.M. Manuel, C. Ferreira, L. F. Melo, O.C. Nunes , F.J. Monteiro, M.P. Ferraz, “A modular reactor to simulate biofilm development in orthopedic materials”, International Microbiology, 16(3), p. 191 (2013).
O.Y. Alothman, F.N. Almajhdi H. Fouad, “Effect of gamma radiation and accelerated aging on the mechanical and thermal behavior of HDPE/HA nano-composites for bone tissue regeneration”, BioMedical Engineering OnLine, 12(95) (2013).
H. Fouad, R. Elleithy, O.Y. Alothman, “Thermo-mechanical, Wear and Fracture Behavior of High-density Polyethylene/Hydroxyapatite Nano Composite for Biomedical Applications: Effect of Accelerated Ageing”, Journal of Materials Science & Technology, 29(6), p. 573 (2013).
S.C. Rodrigues, C.L. Salgado, A. Sahu, M.P. Garcia, M.H. Fernandes, F.J. Monteiro.“Preparation and characterization of collagen-nanohydroxyapatite biocomposite scaffolds by cryogelation method for bone tissue engineering applications”, Journal of Biomedical Materials Research Part A., 101A(4), p. 1980 (2013).
Woo, K.-D.; Kim, S.-H.; Kang, D.-S.; Kim, D.-G., “Microstructure and Biocompatibility of Ti-Nb-Si-HA Composites Fabricated by Rapid Sintering Using HEMM Powders”, Korean Journal of Materials Research 23(7) p. 353 (2013).
H. G. Palacios, “Inducción de transparencia a cuerpos cerámicos de alto y bajo punto de fusión usando sinterizado convencional y por arco eléctrico SPS”, Master Thesis in Tecnología Avanzada, Centro de Investigación e Innovación Tecnológica, Instituto Politécnico Nacional, México (2013).
X. Wang, Y. Chen, L. Xu, Z. Liu, K.-D. Woo, “Effects of Sn content on the microstructure, mechanical properties and biocompatibility of Ti–Nb–Sn/hydroxyapatite biocomposites synthesized by powder metallurgy”, Materials & Design, 49 p. 511 (2013).
A. Carvalho, A. Pelaez-Vargas, D. Gallego-Perez, L. Grenho, M.H. Fernandes, A.H. De Aza, M.P. Ferraz, D.J. Hansford, F.J. Monteiro, “Micropatterned silica thin films with nanohydroxyapatite micro-aggregates for guided tissue regeneration”, Dental Materials, 28(12), p. 1250 (2012)
L.R. Rodrigues, M.A. Ávila, F.J. Monteiro, C. A. Zavaglia, “Synthesis and characterization of nanocrystalline hydroxyapatite gel and its application as scaffold aggregation”, Materials Research, 15(6) p. 974 (2012)
M.S. Laranjeira, “Reciprocal interaction between human microvascular endothelial cells and mesenchymal stem cells on macroporous granules of nanostructured-hydroxyapatite agglomerates”, PhD Thesis in Biomedical Engineering, Faculdade de Engenharia, Universidade do Porto (2012).
M. Ribeiro, F.J. Monteiro, M.P. Ferraz, “Staphylococcus aureus and Staphylococcus epidermidis adhesion to nanohydroxyapatite in the presence of model proteins”, Biomedical Materials, 7(4) (2012).
L.R. Rodrigues, A.B. Almeida, D.F. Feliciano, C.E. Raposo-Amaral, M.R. Passos-Bueno, B.V. Alamada, M.H. Fernandes, F.J. Monteiro, C. A. Zavaglia, “Inclusão de células mesenquimais em scaffold de fosfato de cálcio para testes in vivo e in vitro”, presented at the “7 Congresso Latino-Americano de Orgãos Artificiais e Biomateriais”, Natal, Brazil (2012).
L. Grenho, F.J. Monteiro, M.P. Ferraz, “Synthesis and antibacterial activity of nanohydroxyapatite/ZnO nanoparticle composite”, European Cells and Materials, 23(S2), p. 17 (2012).
J. Barros, C.M. Manuel, L. Grenho, F.J. Monteiro, L. Melo, O.C. Nunes , M.P. Ferraz, “Design of a modular reactor for biofilm formation studies in biomaterials”, European Cells and Materials, 23(S2), p. 11 (2012).
M. Ribeiro, F.J. Monteiro, M.P. Ferraz, “Influence of surface proteins on Staphylococcus epidermidis adhesion to nanohydroxyapatite as a substrate for bone regeneration”, European Cells and Materials, 23(S2), p. 25 (2012).
L. Grenho, C. Manso, F. J. Monteiro, M. P. Ferraz, “Adhesion of Staphylococcus aureus, Staphylococcus epidermidis and Pseudomonas aeruginosa onto nanohydroxyapatite as a bone regeneration material”, Journal of Biomedical Materials Research Part A., 100A(7), p. 1823 (2012).
M.S. Laranjeira, M.H. Fernandes, F.J. Monteiro, “Preparation and in vitro biological studies of porous granules with nanostructured hydroxyapatite”, Third I3S Scientific Retreat, Póvoa de Varzim, Portugal, p. 187 (2012).
C. Yuyong, W. Xiaopeng, X. Lijuan, L. Zhiguang, K. D. Woo, “Tribological behavior study on Ti–Nb–Sn/hydroxyapatite composites in simulated body fluid solution”, Journal of the Mechanical behaviour of Biomedical Materials 10, p. 97 (2012).
L. Grenho, M.P. Ferraz, F.J. Monteiro, “Staphylococci adhesion on nanohydroxyapatite”, Bone, 48(S2), p. 240 (2011).
M.S. Laranjeira, F.J. Monteiro, M.H. Fernandes, “Co-culture of human bone marrow stromal cells (HBMSC) and human dermal microvascular endothelial cells (HDMEC) on nano-hydroxyapatite (HA) surfaces”, Histology and Histopathology, 26(S1) (2011).
S.C. Rodrigues, A. Sahu, C.L. Salgado, F.J. Monteiro, “Preparation of collagen-hydroxyapatite biocomposite scaffolds by cryogelation method for tissue engineering applications”, Histology and Histopathology, 26(S1) (2011).
M. Ribeiro, “Study of nanostructured hydroxyapatite based surfaces to prevent biofilm formation associated to implant infections” MSc Thesis in Biomedical Engineering, Faculdade de Engenharia, Universidade do Porto (2011).
A. Carvalho, “Development of nanostructured and bioactive surfaces onto ceramic substrates”, MSc Thesis in Biomedical Engineering, Faculdade de Engenharia, Universidade do Porto (2011).
M.S. Laranjeira, M.H. Fernandes, F.J. Monteiro, “Preparation and physicochemical/structural characterization of macroporous nanostructured-hydroxyapatite granules”, COLAOB Annals 2010, Rio Grande do Sul, Brasil.
M.S. Laranjeira, M.H. Fernandes, F.J. Monteiro, “Innovative macroporous granules of nanostructured hydroxyapatite agglomerates”, Journal of Biomedical Materials Research Part A, 95A(3), p. 891-900 (2010).
N. Ribeiro, S.R. Sousa, F.J. Monteiro, “Influence of crystallite size of nanophased hydroxyapatite on fibronectin and osteonectin adsorption and on MC3T3-E1 osteoblast adhesion”, Journal of Colloid and Interface Science , 351(2), p. 398-406 (2010).
J. M. Coelho, J. A. Moreira, A. Almeida, F. J. Monteiro, “Synthesis and characterization of HAp nanorods from a cationic surfactant template method”, J Mater Sci: Mater Med, 21(9), p. 2543-2549 (2010).
L. Grenho, M.P. Ferraz, F.J. Monteiro, “Adhesion of different staphylococcus epidermidis strains to nano-hydroxyapatite”, Poster presented at the “I3S Retreat”, Póvoa do Varzim, Portugal (2010).
L. Grenho, “Estudo da adesão bacteriana a biomateriais nanofásicos” MSc Thesis, Universidade Fernando Pessoa (2010).
N. Ribeiro, S. Sousa, F.J. Monteiro, “Human Fibronectin Adsorption onto Nanohydroxiapatite”, Poster presented at the “22nd European Conference of Biomaterials”, Lausanne, Switzerland (2009).
