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nanoXIM•CarePaste is a synthetic nano-hydroxyapatite water based suspension ingredient specially designed to be easily incorporated in oral care products such as toothpastes, mouthwashes, gels and other professional dental products.

The hydroxyapatite nanoparticles comprised in nanoXIM•CarePaste form a perfectly aligned structure of nanocrystals identical to enamel hydroxyapatite which enables enamel remineralization.

Due to the nanometric size of hydroxyapatite particles, nanoXIM•CarePaste is able to seal the dentin tubules and prevent nerve exposure to external stimuli, resulting in reduced dental hypersensitivity.

nanoXIM•CarePaste product is a NATRUE approved raw-material, vegan and allergens & parabens free.

 

 

   Benefits

 

Reduction of dental hypersensitivity by effective occlusion of dentin tubules

Promotion of enamel remineralization due to high affinity for binding with teeth surface

Smoothes and protects teeth surface from the damage caused by acids in food and drink

 

   Features

 

Hydroxyapatite nanoparticles (< 50 nm)

High surface area

Low Relative Dentin Abrasivity (RDA < 10)

Synthetic material

Self-preserved product (Parabens Free)

Shelf life 3 years

 

 

 

   Technical Data Sheet

 

nanoXIM•CarePaste comprises nano-hydroxyapatite particles with typical particle size below 50 nm in a rod-like shape (typically 30-40 nm length and 5-10 nm width). This product is an aqueous suspension of 15.5 wt% hydroxyapatite and 4.5 wt% potassium chloride.

 

Reference  Hydroxyapatite (wt%) cart
nanoXIM•CarePaste 15.5±0.5 ADD

 


nanoXIM•CarePaste

High Resolution TEM of
nanoXIM•CarePaste

Electron crystallography image
of nanoXIM•CarePaste

 

 

 

Click here to know more about the SCCS safety approval of our nano-hydroxyapatite.

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Effectiveness of nanoXIM•CarePaste on dentin tubule occlusion and enamel remineralization

 

Dental hypersensitivity is a common and relevant clinical problem.

This condition arises as a result of continuous teeth erosion and it is characterized by a short and sharp pain, being a significant concern for patients. Dental hypersensitivity is usually treated by incorporating desensitizing agents in toothpastes.

nanoXIM•CarePaste when used in toothpaste formulations effectively occludes the dentinal tubules and consequently reduces dental hypersensitivity. It is also demonstrated that toothpastes containing nanoXIM•CarePaste are able to reduce early carious lesions by remineralizing the enamel surface.

 

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Clinical efficacy of a dentifrice containing nanoXIM•CarePaste

 

This clinical trial compared the effectiveness of a toothpaste containing nanoXIM•CarePaste in reducing dental hypersensitivity, in comparison with two other dentifrices without nanoXIM•CarePaste.

The toothpaste with nanoXIM•CarePaste performed better than dentifrice 1 and dentifrice 2 in 75 % and 100 % of the cases, respectively.

Therefore, nanoXIM•CarePaste was the most effective in the treatment of dental hypersensitivity allowing a superior pain reduction after 3 months. In addition, nanoXIM•CarePaste provided a faster pain relief immediately after 2 weeks of treatment for all the tests performed.

 

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After 2 weeks of treatment, the nanoXIM•CarePaste toothpaste provided a superior pain relief when compared with Dentifrice 1 and Dentifrice 2

 

 

Nano-hydroxyapatite toothpaste vs Fluoride toothpaste in reducing dental hypersensitivity

 

In the present clinical trial, it was evaluated the efficacy of a toothpaste containing nanoXIM•CarePaste in reducing dental hypersensitivity, in comparison with a toothpaste containing fluoride. Hypersensitivity was assessed using tactile and air blast stimuli.

This study revealed that the toothpaste containing nanoXIM•CarePaste was able to significantly reduce dental hypersensitivity, for both tactile and air blast stimuli, which was not achieved with the placebo and fluoride toothpaste.

 

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nanoXIM•CarePaste reduced dental hypersensitivity immediately after 2 weeks, providing a fast and effective pain relief.

 

 

 

 

 

 

Tooth whitening with an experimental toothpaste containing hydroxyapatite nanoparticles

R. Shang, D. Kaisarly, K.-H. Kunzelmann, “Tooth whitening with an experimental toothpaste containing hydroxyapatite nanoparticles”, BMC Oral Health 22(331), (2022).

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Non-oxidative Tooth Whitening Effect of Hydroxyapatite on Bovine Enamel

R. Shang, “Non-oxidative Tooth Whitening Effect of Hydroxyapatite on Bovine Enamel”, PhD thesis in Dentistry, Faculty of Medicine Ludwig-Maximilians-Universität München (2022).

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Prospective, Single-Centre, Non-Randomized, Open-Label, Single-Arm, Post Marketing Study to Evaluate Safety and Efficacy of DENTE91® Mom Toothpaste and DENTE91® Mom Mouthwash in Pregnant Females

F. Tekrawala, H. Shah, A. Singh, J. Pariyani, “Prospective, Single-Centre, Non-Randomized, Open-Label, Single-Arm, Post Marketing Study to Evaluate Safety and Efficacy of DENTE91® Mom Toothpaste and DENTE91® Mom Mouthwash in Pregnant Females”, Paripex - Indian Journal of Research, 11(12), p. 161 (2022).

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Biomimetic tooth-whitening effect of hydroxyapatite-containing mouthrinses after long-term simulated oral rinsing

R. Shang, K.-H. Kunzelmann, “Biomimetic tooth-whitening effect of hydroxyapatite-containing mouthrinses after long-term simulated oral rinsing”, American Journal of Dentistry 34(6), p. 307 (2021).

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A Radical-Free Approach to Teeth Whitening

M. Pascolutti, D. de Oliveira, “A Radical-Free Approach to Teeth Whitening”, Dentistry Journal; 9(12), p. 148 (2021).

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In Vitro Biocompatibility Assessment of Nano-Hydroxyapatite

R.-M. Kavasi, C.C. Coelho, V. Platania, P.A. Quadros, M. Chatzinikolaidou, “In Vitro Biocompatibility Assessment of Nano-Hydroxyapatite”, Nanomaterials, 11(5):1152, doi.org/10.3390/nano11051152 (2021).

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Effect of high concentration nano-hydroxyapatite serum on shear bond strength of metal brackets following three different enamel surface preparation methods: An in vitro study

N. Babanouri, A.R. Ghafoori, S. Ajami, A. Mahdian, “Effect of high concentration nano-hydroxyapatite serum on shear bond strength of metal brackets following three different enamel surface preparation methods: An in vitro study”, International Orthodontics, 19(1), p. 123 (2021).

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Physical and Chemical Characterizations of Novel Bioactive Caries Detecting Solution

G. Shashirekha, K.K. Sushant, N. Binita, J. Amit, M. Neeta, “Physical and Chemical Characterizations of Novel Bioactive Caries Detecting Solution”, Dental Hypotheses, 12(1), p. 8 (2021).

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Clinical efficacy of single application of plain nano hydroxyapatite paste in reducing dentine hypersensitivity – A randomized clinical trial

D.N. Alharith, M. Al-Omari, R. Almnea, R. Basri, A.H. Alshehri, A.A. Al-Nufiee, “Clinical efficacy of single application of plain nano hydroxyapatite paste in reducing dentine hypersensitivity – A randomized clinical trial”, Saudi Endodontic Journal, 11 (1), p. 24 (2021).

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Effects of Experimental Nano-Hydroxyapatite Pastes on Remineralization of Early Demineralized Enamel

A. Vacharangkura, S. Kunawarote, “Effects of Experimental Nano-Hydroxyapatite Pastes on Remineralization of Early Demineralized Enamel”, Proceedings of RSU International Research Conference 2021, p. 109 (2021).

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Comparative evaluation of remineralization potential of nanohydroxyapatite crystals, bioactive glass, casein phosphopeptide-amorphous calcium phosphate, and fluoride on initial enamel lesion (scanning electron microscope analysis) – An in vitro study

R.D. Geeta, S. Vallabhaneni, K. Fatima, “Comparative evaluation of remineralization potential of nanohydroxyapatite crystals, bioactive glass, casein phosphopeptide-amorphous calcium phosphate, and fluoride on initial enamel lesion (scanning electron microscope analysis) – An in vitro study”, Journal of Conservative Dentistry, 23(3), p. 275 (2020).

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In Vitro Study on the Effect of a New Bioactive Desensitizer on Dentin Tubule Sealing and Bonding

M.N. Luong, L. Huang, D.C.N. Chan, A. Sadr, “In Vitro Study on the Effect of a New Bioactive Desensitizer on Dentin Tubule Sealing and Bonding”, Journal of Functional Biomaterials, 11(2), p. 38 (2020).

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Novel bioactive caries-detecting dye solution: Cytotoxicity, antimicrobial activity, scanning electron microscope, and stereomicroscopic analysis in diagnosis of dental caries

G. Shashirekha, A. Jena, N. Mohanty, S.K. Kamilla, “Novel bioactive caries-detecting dye solution: Cytotoxicity, antimicrobial activity, scanning electron microscope, and stereomicroscopic analysis in diagnosis of dental caries”, Journal of Conservative Dentistry, 23 (1), p. 79 (2020)

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Enhanced toothpaste and kits

D. Debaun, “Enhanced toothpaste and kits”, WO2021046047A1 patent (2020).

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Nanohydroxyapatite (n-HAp) as a pickering stabilizer in oil-in-water (O/W) emulsions: a stability study

A. Ribeiro, Y.A. Manrique, I.C.F.R. Ferreira, M.F. Barreiro, J.C.B. Lopes, M.M. Dias, “Nanohydroxyapatite (n-HAp) as a pickering stabilizer in oil-in-water (O/W) emulsions: a stability study”, Journal of Dispersion Science and Technology, DOI: 10.1080/01932691.2020.1845199 (2020).

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Nano-hydroxyapatite in oral care cosmetics: characterization and cytotoxicity assessment

C.C. Coelho, L. Grenho, P. Gomes, P.A. Quadros and M.H. Fernandes, “Nano-hydroxyapatite in oral care cosmetics: characterization and cytotoxicity assessment”, Scientific Reports 9, Article number: 11050 (2019).

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Clinical efficacy of nano-hydroxyapatite in dentin hypersensitivity: A systematic review and meta-analysis

C.M. Alencar, B.L.F. Paula, M.I.G. Ortiz, M.B. Magno, C.M. Silva, L.C. Maia, “Clinical efficacy of nano-hydroxyapatite in dentin hypersensitivity: A systematic review and meta-analysis”, Journal of Dentistry 82, p. 11 (2019).

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Comparative evaluation of neodymium-doped yttrium aluminum garnet laser with nanocrystalline hydroxyapatite dentifrices and herbal dentifrices in the treatment of dentinal hypersensitivity

R.K. Yadav, U.P. Verma, R. Tiwari, “Comparative evaluation of neodymium-doped yttrium aluminum garnet laser with nanocrystalline hydroxyapatite dentifrices and herbal dentifrices in the treatment of dentinal hypersensitivity”, Natl J Maxillofac Surg., 10(1), p.78 (2019).

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Comparison of efficacy of nanohydroxyapatite desensitizer, ND:YAG Laser and their combined effect in the treatment of dentin hypersensitivity: a clinical study

A. Arya, A. Arora, “Comparison of efficacy of nanohydroxyapatite desensitizer, ND:YAG Laser and their combined effect in the treatment of dentin hypersensitivity: a clinical study”, International Journal of Scientific Research, 8(9), p. 54 (2019).

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Effectiveness of Calcium Phosphate Desensitising Agents in Dental Hypersensitivity Over 24 Weeks of Clinical Evaluation

P. Usai, V. Campanella, G. Sotgiu, G. Spano, R. Pinna, S. Eramo, L. Saderi, F. Garcia-Godoy, G. Derchi, G. Mastandrea, E. Milia, “Effectiveness of Calcium Phosphate Desensitising Agents in Dental Hypersensitivity Over 24 Weeks of Clinical Evaluation”, Nanomaterials, 9, 1748; doi:10.3390/nano9121748 (2019).

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A Comparative Evaluation of Three Different Remineralizing Agents on Aertificially created Surface Carious Lesion: An In Vitro study

T. Sowmiya, “A Comparative Evaluation of Three Different Remineralizing Agents on Aertificially created Surface Carious Lesion: An In Vitro study.”, MSc thesis, Vivekanandha Dental College for Women, Tiruchengode (2019).

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Safety Assessment of Nano-Hydroxyapatite as an Oral Care Ingredient according to the EU Cosmetics Regulation
 

J.M. Ramis, C.C. Coelho, A. Córdoba, P.A. Quadros, M. Monjo, “Safety Assessment of Nano-Hydroxyapatite as an Oral Care Ingredient according to the EU Cosmetics Regulation”, Cosmetics 5(3), 53 (2018).

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Reducing dentine hypersensitivity with nano-hydroxyapatite toothpaste: a double-blind randomized controlled trial

M. Vano, G. Derchi, A. Barone, R. Pinna, P. Usai, U. Covani, “Reducing dentine hypersensitivity with nano-hydroxyapatite toothpaste: a double-blind randomized controlled trial”, Clinical Oral Investigations, 22(1), p. 313 (2018).

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Experimental mouth rinse with nano-HAp to be used at home for dental erosion treatment

F.S. Calazans, M.J. Anjos, R.S. Santos, R.P. Mendonça, T.M.J. Ferreira, G.R. Pereira, J.T. Assis, M.S. Miranda, “Experimental mouth rinse with nano-HAp to be used at home for dental erosion treatment”, J Clin Dent Res., 15(2), p.62 (2018).

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Comparative Evaluation of Surface Microhardness of Artificially Demineralized Human Enamel with Nano Hydroxyapatite, Calcium Phosphate, and Potassium Nitrate Remineralizing Agents: An In Vitro Study

P. Madhusudanan, P. SV, R. Pillai, N.O. Varghese, S. George, A. Antony, “Comparative Evaluation of Surface Microhardness of Artificially Demineralized Human Enamel with Nano Hydroxyapatite, Calcium Phosphate, and Potassium Nitrate Remineralizing Agents: An In Vitro Study”, Conservative Dentistry and Endodontic Journal, 3(2), p. 50 (2018).

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Evaluation of the remineralization potential of two non-fluoridated remineralizing pastes using scanning electron microscope with energy dispersive X-ray analysis: A randomized controlled in-vitro trial

V. Vijayasankari, “Evaluation of the remineralization potential of two non-fluoridated remineralizing pastes using scanning electron microscope with energy dispersive X-ray analysis: A randomized controlled in-vitro trial”, MSc Thesis of Dental Surgery, The Tamil Nadu Dr. M.G.R. Medical University (2018).

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Comparing the effectiveness of four desensitizing toothpastes on dentinal tubule occlusion: A scanning electron microscope analysis
 

A. Jena, S. Kala, G. Shashirekha, “Comparing the effectiveness of four desensitizing toothpastes on dentinal tubule occlusion: A scanning electron microscope analysis”, Journal of Conservative Dentistry, 20(4), p. 269 (2017).

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Poly(Nisopropylacrylamide)-hydroxyapatite nanocomposites as thermoresponsive filling materials on dentinal surface and tubules

P. Tempesti, G.S. Nicotera, M. Bonini, E. Fratini, P. Baglioni, “Poly(Nisopropylacrylamide)-hydroxyapatite nanocomposites as thermoresponsive filling materials on dentinal surface and tubules”, Journal of Colloid and Interface Science doi: https://dx.doi.org/10.1016/j.jcis.2017.09.001 (2017).

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Evaluation of efficiency of two nanohydroxyapatite remineralizing agents with a hydroxyapatite and a conventional dentifrice: A comparative In vitro study

A. Singh, B. Shetty, C.M. Mahesh, V.P. Reddy, B.S. Chandrashekar, S. Mahendra, “Evaluation of efficiency of two nanohydroxyapatite remineralizing agents with a hydroxyapatite and a conventional dentifrice: A comparative In vitro study”, The Journal of Indian Orthodontic Society, 51(2), p. 92 (2017).

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Effect of nano-hydroxyapatite toothpaste on microhardness of artificial carious lesions created on extracted teeth
 

A. Ebadifar, M. Nomani, S.A. Fatemi, “Effect of nano-hydroxyapatite toothpaste on microhardness of artificial carious lesions created on extracted teeth”, Journal of Dental Research, Dental Clinics, Dental Prospects, 11(1), p. 14. (2017).

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Comparative Evaluation of Effect of Nano-hydroxyapatite and 8% Arginine Containing Toothpastes in Managing Dentin Hypersensitivity: Double Blind Randomized Clinical Trial
 

S. Anand, F. Rejula, J.V.G. Sam, R. Christaline, M.G. Nair, S. Dinakaran, “Comparative Evaluation of Effect of Nano-hydroxyapatite and 8% Arginine Containing Toothpastes in Managing Dentin Hypersensitivity: Double Blind Randomized Clinical Trial”, Acta Medica (Hradec Králové), 60(3), p. 114 (2017).

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An In-vitro Comparison of Nano Hydroxyapatite, Novamin and Proargin Desensitizing Toothpastes - A SEM Study

R. Kulal, I. Jayanti, S. Sambashivaiah, S. Bilchodmath, “An In-vitro Comparison of Nano Hydroxyapatite, Novamin and Proargin Desensitizing Toothpastes - A SEM Study”, Journal of Clinical and Diagnostic Research 10(10), p. 51 (2016).

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Reduction in Dental Hypersensitivity with Nano-Hydroxyapatite, Potassium Nitrate, Sodium Monoflurophosphate and Antioxidants

S. B. Low, E. P. Allen, E. D. Kontogiorgos, “Reduction in Dental Hypersensitivity with Nano-Hydroxyapatite, Potassium Nitrate, Sodium Monoflurophosphate and Antioxidants”, The Open Dentistry Journal, 9, p. 92 (2015).

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Estudio comparativo in vitro del grado de remineralización del esmalte dental con el uso de nanopartículas de hidroxiapatita en dientes extraídos con y sin brackets cementados en ellos

M. Jiménez Ochoa, “Estudio comparativo in vitro del grado de remineralización del esmalte dental con el uso de nanopartículas de hidroxiapatita en dientes extraídos con y sin brackets cementados en ellos”, MSc Thesis Ortodoncia, Universidad San Francisco de Quito, Ecuador (2015).

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Tooth bleaching with hydrogen peroxide and nano-hydroxyapatite: A 9-month follow-up randomized clinical trial.

M. Vano, G. Derchi, A. Barone, A. Genovesi, U. Covani, “Tooth bleaching with hydrogen peroxide and nano-hydroxyapatite: A 9-month follow-up randomized clinical trial.”, International Journal of Dental Hygiene, 13(4), p. 301 (2015).

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Comparison of efficacy of three different desensitizing agents for in-office relief of dentin hypersensitivity: A 4 weeks clinical study

A. Jena, G. Shashirekha, “Comparison of efficacy of three different desensitizing agents for in-office relief of dentin hypersensitivity: A 4 weeks clinical study”, Journal of Conservative Dentistry, 18(5), p. 389 (2015).

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Evaluation of the Efficacy of Commercially Available Nano-Hydroxyapatite Paste as a Desensitizing Agent

M. Amin, R. Mehta, S. Duseja, K. Desai, “Evaluation of the Efficacy of Commercially Available Nano-Hydroxyapatite Paste as a Desensitizing Agent”, Advances in Human Biology 5(1), p. 34 (2015).

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Evaluation of Dentifrice Containing Nano-hydroxyapatite for Dentinal Hypersensitivity: A Randomized Controlled Trial

N. M. Gopinath, J. John, N. Nagappan, S. Prabhu, E. S. Kumar, “Evaluation of Dentifrice Containing Nano-hydroxyapatite for Dentinal Hypersensitivity: A Randomized Controlled Trial”, Journal of International Oral Health, 7(8), p. 118 (2015).

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Effectiveness of nano-hydroxyapatite toothpaste in reducing dentin hypersensitivity: A double-blind randomized controlled trial

M. Vano, G. Derchi, A. Barone, U. Covani, “Effectiveness of nano-hydroxyapatite toothpaste in reducing dentin hypersensitivity: A double-blind randomized controlled trial”, Quintessence International, 45(8), p. 703 (2014). 

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An In-Vivo Comparative Study of the Efficacy of Propolis, Nano-Hydroxyapatite and Potassium Nitrate Containing Desensitizing Agents

N. VJ, S. Thakur, “An In-Vivo Comparative Study of the Efficacy of Propolis, Nano-Hydroxyapatite and Potassium Nitrate Containing Desensitizing Agents”, Research and Reviews: Journal of Dental Sciences, 2(2), p. 113 (2014). 

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A Comparison of Clinical Efficacy of Dentifrices Containing Calcium Sodium Phosphosilicate, Nanoparticle Hydroxyapatite and a Dentifrice Containing Casein Phosphopeptide Amorphous Calcium Phosphate on Dentinal Hypersensitivity

Pinojj, A. Shetty, D. Shetty, S. Shetty, “A Comparison of Clinical Efficacy of Dentifrices Containing Calcium Sodium Phosphosilicate, Nanoparticle Hydroxyapatite and a Dentifrice Containing Casein Phosphopeptide Amorphous Calcium Phosphate on Dentinal Hypersensitivity - A Comparative Triple Blind Randomized Study”, Advances in Human Biology, 4(2) p. 57 (2014).

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Evaluation of the Clinical Efficacy of a new Desensitizing Tooth Paste Containing Nano-crystalline Hydroxyapatite in Dentine Hypersensitivity Patients : A Double Blind Randomized Controlled Clinical Trial

P. Verma, U. Gupta, V. Dodwad, B. Kukreja, K. Arora, “Evaluation of the Clinical Efficacy of a new Desensitizing Tooth Paste Containing Nano-crystalline Hydroxyapatite in Dentine Hypersensitivity Patients : A Double Blind Randomized Controlled Clinical Trial”, Journal of Dental Specialities, 1(2), p. 47 (2013).

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