nanoXIM•CarePaste is a synthetic nano-hydroxyapatite water based suspension ingredient specially designed to be easily incorporated in oral care products such as toothpastes, mouthwashes, gels and other professional dental products.
The hydroxyapatite nanoparticles comprised in nanoXIM•CarePaste form a perfectly aligned structure of nanocrystals identical to enamel hydroxyapatite which enables enamel remineralization.
Due to the nanometric size of hydroxyapatite particles, nanoXIM•CarePaste is able to seal the dentin tubules and prevent nerve exposure to external stimuli, resulting in reduced dental hypersensitivity.
Reduction of dental hypersensitivity by effective occlusion of dentin tubules
Promotion of enamel remineralization due to high affinity for binding with teeth surface
Smoothes and protects teeth surface from the damage caused by acids in food and drink
Hydroxyapatite nanoparticles (< 50 nm)
High surface area
Low Relative Dentin Abrasivity (RDA < 10)
Self-preserved product (Parabens Free)
Shelf life 3 years
nanoXIM•CarePaste comprises nano-hydroxyapatite particles with typical particle size below 50 nm in a rod-like shape (typically 30-40 nm length and 5-10 nm width) suspended in pure water with hydroxyapatite concentration of 15.5 wt%.
as Pb (ppm)
|Shelf life (years)|
|nanoXIM•CarePaste||15.5±0.5||4.5±0.5||≤ 100||≤ 20||3|
High Resolution TEM of
Electron crystallography image
Dental hypersensitivity is a common and relevant clinical problem.
This condition arises as a result of continuous teeth erosion and it is characterized by a short and sharp pain, being a significant concern for patients. Dental hypersensitivity is usually treated by incorporating desensitizing agents in toothpastes.
nanoXIM•CarePaste when used in toothpaste formulations effectively occludes the dentinal tubules and consequently reduces dental hypersensitivity. It is also demonstrated that toothpastes containing nanoXIM•CarePaste are able to reduce early carious lesions by remineralizing the enamel surface.
This clinical trial compared the effectiveness of a toothpaste containing nanoXIM•CarePaste in reducing dental hypersensitivity, in comparison with two other dentifrices without nanoXIM•CarePaste.
The toothpaste with nanoXIM•CarePaste performed better than dentifrice 1 and dentifrice 2 in 75 % and 100 % of the cases, respectively.
Therefore, nanoXIM•CarePaste was the most effective in the treatment of dental hypersensitivity allowing a superior pain reduction after 3 months. In addition, nanoXIM•CarePaste provided a faster pain relief immediately after 2 weeks of treatment for all the tests performed.
In the present clinical trial, it was evaluated the efficacy of a toothpaste containing nanoXIM•CarePaste in reducing dental hypersensitivity, in comparison with a toothpaste containing fluoride. Hypersensitivity was assessed using tactile and air blast stimuli.
This study revealed that the toothpaste containing nanoXIM•CarePaste was able to significantly reduce dental hypersensitivity, for both tactile and air blast stimuli, which was not achieved with the placebo and fluoride toothpaste.
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